How wrong to have been so negative, how wrong to have been so gloomy, how wrong to have run away from life, how wrong to have said no, again and again, instead of yes.
Depression, when it's clinical, is not a metaphor. It runs in families, and it's known to respond to medication and to counseling. However truly you believe there's a sickness to existence that can never be cured, if you're depressed you will sooner or later surrender and say: I just don't want to feel bad anymore. The shift from depressive realism to tragic realism, from being immobilized by darkness to being sustained by it, thus strangely seems to require believing in the possibility of a cure.
Even in an intensely mediated world, in a world that offers at least the illusion of radical self-invention and radical freedom of choice, I as a novelist am drawn to the things you can't get away from. Because much of the promise of radical self-invention, of defining yourself through this marvelous freedom of choice, it's just a lie. It's a lie that we all buy into, because it helps the economy run.