...Search for the cause may be a hopeless pursuit because most disease states are the indirect outcome of a constellation of circumstances.
Pathological states are the consequence of several determinate factors acting simultaneously...The manifestations of any given agent differ profoundly from one person to another. ...Each noxious agent can express itself by a great variety of different pathological states. ...Different agents can elicit similar reactions. ...The total environment and the (interior medium) constitute a multifactorial system.