Certain roles are more challenging than others, but I haven't come across one yet that I can't tackle.
In film you have the script months ahead of time often, for a good film, but in television it seems like you might not get the script until a week or two weeks before you've got to film it. It's a little weird, but also quite challenging. It reminds me of repertory theatre.
Not everybody can do the comic book adaptation thing and make it believable. It is challenging.