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Wile E. Coyote is a coyote with nothing but good intentions. But Road Runner comes along and is unattainable, he wants it and can't get it, and thus he becomes a villain that is impossible to be around. Bill O'Reilly is a villain that is so in love with himself and the sound of his voice that he's literally become the personification of evil.

Source: collider.com
Wile E. Coyote is a coyote with nothing but good intentions. But Road Runner comes along and is unattainable, he wants it and can't get it, and thus he becomes a villain that is impossible to be around. Bill O'Reilly is