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The factor most ignored in discussing interstellar flight is the kinetic energy that must be invested in the ship to make its tons of matter move at a substantial fraction of the speed of light.

Bernard M. Oliver, Len Cutler (1997). “The Selected Papers of Bernard M. Oliver”
The factor most ignored in discussing interstellar flight is the kinetic energy that must be invested in the ship to make its tons of matter move at a substantial fraction of the speed of light.