I don't think we should just 'muddle through' and ignore the question of life's meaning. Or better, perhaps, I don't think it is a question that can be ignored once the business of asking about the worth and significance of what one is doing - one's work, one's pleasures, one's ambitions and so on - has got going. You can't at any point stop the urge to ask Tolstoy's questions, '... and then what?', 'What's the point of that?'.