The principal cause of suffering is craving. Once craving is eliminated, much suffering will be eliminated. Still more suffering will be eliminated once ignorance is eliminated. Both craving and ignorance are equally powerful defilements that cause suffering.
Bhante Henepola Gunaratana (2010). “Beyond Mindfulness in Plain English: An Introductory Guide to Deeper States of Meditation”, p.33, ReadHowYouWant.com