The Principle of Tolerance, fixed once for all the realization that all knowledge is limited. It is an irony of history that at the very time when this was being worked out, there should rise, under Hitler in Germany and other tyrants elsewhere, a counter-conception: a principle of monstrous certainty. When the future looks back on the 1930's, it will think of them as a crucial confrontation of culture as I have been expounding it - the ascent of man against the throwback to the despots' belief that they have absolute certainty.
"The Ascent of Man" (Episode 11: "Knowledge or Certainty"), 1973.