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One of the challenges associated with a company becoming large is that companies become hierarchical. They become bureaucratic. They become slow. They become risk averse.

"Big Pharma’s Delicate Dance on Drug Prices". Interview with Peter Loftus, www.wsj.com. February 21, 2016.
One of the challenges associated with a company becoming large is that companies become hierarchical. They become bureaucratic. They become slow. They become risk averse.