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The biggest handicap in research is an ability to think outside the box. The handicap is being encumbered by all the conventional wisdom in a given field.

Aubrey de Grey
Thinking, Research, Fields
"How Beer, Oprah and Sergey Brin Can Help Cure Aging". Interview with Steven Leckart, www.wired.com. October 19, 2010.
The biggest handicap in research is an ability to think outside the box. The handicap is being encumbered by all the conventional wisdom in a given field.