You are to consider that a certain melancholy and often a certain irascibility accompany advancing age: indeed it might be said that advancing age equals ill-temper. On reaching the middle years a man perceives that he is no longer able to do certain things, that what looks he may have had are deserting him, that he has a ponderous great belly, and that however much he may yet burn he is no longer attractive to women; and he rebels. Fortitude, resignation and philosophy are of more value than any pills, red, white or blue.
Patrick O'Brian (2011). “The Truelove (Vol. Book 15) (Aubrey/Maturin Novels)”, p.15, W. W. Norton & Company