Each film and each character is a completely new set of challenges. It doesn't feel like you can rest on something you may have done well in the past.
The biggest challenge to being an actor is when you're not working, just being unemployed, the downtime and not having anything to do.
I honesty feel that each film has its own particular challenges.
With 'Hail, Caesar!' it was about all the skill sets I had to learn, but each movie requires a different way of working. You're a piece in a new world, and there is always a difficult part within that world. For me, it's not consistent from movie-to-movie, each film has a central challenge.