My characters aren't losers. They're rebels. They win by their refusal to play by everyone else's rules.
I did a comedy with Al Franken about his character Stuart Smalley, which was really about alcoholism and addiction and codependency. It had some painful stuff in it. When we showed it to focus groups, some of them actually said, "If I want to see a dysfunctional family, I'll stay home."
The rule of thumb for a director or producer - which prevents them from just sticking their names on everything - is that you have to contribute substantially more than 50 percent of the character dialogue and story.
My only conclusion about structure is that nothing works if you don't have interesting characters and a good story to tell.
With both Caddyshack and Vacation, it's not like the subjects were serious enough that they engaged my interest for another round. I love the characters, and the actors were great, but I didn't see the need to make another Vacation movie.