I had five years of failure, really, before I had the first initial sign of success.
I became aware of the very complex internal organization in a cell from the basic science classes, and it made me think about how all that could work. It seemed like a great mystery, especially how organelles in the cell can be arranged in three dimensions, and how thousands of proteins could find their way to the right location in the cells.
When I was a college student at Yale, I was studying physics and mathematics and was absolutely intent on becoming a theoretical physicist.
I started taking a basic biology course, and I really loved it. I started asking research questions incessantly. I was drawn very quickly to biology.