When you're standing around for an hour doing stand up it's no big deal but when you're standing around watching a show for an hour - it's a big difference. It's annoying - your feet hurt, your back hurts - it's just not the most comfortable way to see stand-up comedy.
It never hurt Lenny Bruce's career to get arrested for swearing. It did back in the time, but he broke those doors down by doing the stuff that he believed in.
Like any tool [drugs] can help you or hurt you.
Dick Gregory was a great comedian who went and got arrested, did hunger strikes, protests. It never hurt his career to be outspoken.