The question is whether NGOs that bring protection or aid or reparation therapies are furthering the possibility of self-determination or extending a form of managerial power and paternalism.
Gender assignment is a "construction" and yet many genderqueer and trans people refuse those assignments in part or in full. That refusal opens the way for a more radical form of self-determination, one that happens in solidarity with others who are undergoing a similar struggle.
Popular sovereignty has to be given by a people to itself, and this is the important meaning of self-determination.