I don't know about the romantic comedy route, although never say never.
Women do get drunk, they do get sick and they do get food poisoning. It seems to be a bit of a surprise to people that they are seeing it.
Maybe studios don't want to see women acting in a way that isn't womanly. Maybe people don't.
I lived in Lancaster, Pennsylvania, until eighth grade, and then my high-school years were in Rochester, New York.
I just like to walk around New York, just put my iPod on and walk around.