What basically happens is your hormones get out of whack. Because of the stress in your life your body says, 'I need more hormones.' So, your hormones are trying to produce and produce and produce, and it's even more stressful and it is this wicked cycle.
You need to be able to manage stress because hard times will come, and a positive outlook is what gets you through.
That's what it is to be a grandma. All fun and no stress.