The bottom line for mathematicians is that the architecture has to be right. In all the mathematics that I did, the essential point was to find the right architecture. It's like building a bridge. Once the main lines of the structure are right, then the details miraculously fit. The problem is the overall design.
"Freeman Dyson: Mathematician, Physicist, and Writer". The College Mathematics Journal Interview with Donald J. Albers, January 1994.