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Each new ontological theory, propounded in lieu of previous ones shown to be untenable, has been followed by a new criticism leading to a new scepticism. All possible conceptions have been one by one tried and found wanting; and so the entire field of speculation has been gradually exhausted without positive result: the only result reached being the negative one above stated, that the reality existing behind all appearances is, and must ever be, unknown.

Herbert Spencer (1920). “Synthetic Philosophy ...: First principles. 1920. [v.2-3] The principles of biology. v.1, rev. & enl. ed., 1921”
Each new ontological theory, propounded in lieu of previous ones shown to be untenable, has been followed by a new criticism leading to a new scepticism. All possible conceptions have been one by one tried and found