Probably some of the best things that have ever happened to you in life, happened because you said yes to something. Otherwise things just sort of stay the same.
This is love, to sit with someone you've known forever in a place you've been meaning to go, and watching as their life happens to them until you stand up and it's time to go.
When the most important things in our life happen we quite often do not know, at the moment, what is going on.
In my experience, you get a job for a reason. Your work life happens for a reason.