Guts are important. Your guts are what digest things. But it is your brains that tell you which things to swallow and which not to swallow.
Souls (or minds) are thought of as purely non-physical, they can't be weighed, split in half, heated or cooled, they lack mass, electric charge and so on...but how could they possibly have a cause and effect relationship with bodies that are said to have these, and only these physical properties?