I'm happy to try any genre, from drama to comedy and anything in between. Although, to be fair, for most of my career, I've been at the mercy of what people are willing to put me in.
With comedy, it's a combination of knowing the comedic beat was good - it made you laugh, it made people on the crew laugh. With drama, you do something deep and if your stuff was really effective, the ultimate result is silence. Silence is not necessarily... that would also be the result if you sucked.
I'm still fighting really hard to get any role I get. If it's comedy, I go for the laughs. And if it's drama, I try to tell the truth, and try to play the real stakes of whatever scenario the character's in.