I don't know of a great artist who did not sacrifice and thereby have to wrestle with the depths of loneliness and sadness.
Any great artist is wrestling with their sadness and loneliness, their fears, anxieties and securities, and they're transfiguring those into complicated forms of expression that affect our hearts, minds and souls and remind us of who we are as human beings, the fragility of our human status and the inevitability of death.