Of persons I will say this: it is difficult to tell when they are running aright but easy to see when something has gone awry.
The franchise and the virus work on the same principle, what thrives in one place will thrive in another. You just have to find a sufficiently virulent business plan, condense it into a three-ring binder ― its DNA ― Xerox it, and embed it in the fertile line of a well-traveled highway, preferably one with a left turn lane. Then the growth will expand until it runs up against its property lines.
I really am just trying to tell stories. But stories are often grounded in larger events and themes. They don't have to be - there's a big literature of trailer-park, kitchen-table fiction that's just about goings-on in the lives of ordinary people - but my own tastes run toward stories that in addition to being good stories are set against a backdrop that is interesting to read and learn about.
I was trying to run something to ground that had come to my attention when I was working on the Baroque Cycle. That series, of course, was about the conflict between Newton and Leibniz. Leibniz developed a system of metaphysics called monadology, which looked pretty weird at the time and was promptly buried by Newtonian-style physics.