Comedy and drama are different sides of the same coin. And the thing about comedy and drama is about likability. It's about character first. It's about story. And for me, it's about empathy, and I think the realer someone is, the further you can go either way with them.
You try to make characters you care about, and I think realism helps. Even though this is a high concept, the characters have got to be real.
I think that's the fundamental thing - you can go anywhere you like as long as you're following a character that the audience likes and understands.