Mastery is not a function of I.Q. or natural talent or wealthy parents who can send you to the best school, but rather the result of going through a learning process, fueled by the desire to grow and the persistence to push past any obstacles.
The key to success in any kind of start up is your level of persistence. It's not so much your intellect. The Zuckerburg's, Pages and Brins, that succeed have such a level of belief in what they are doing that they will put up with the kind of crap that most people won't put up with, they are incredibly persistent and resilient.
Our levels of desire, patience, persistence, and confidence end up playing a much larger role in success than sheer reasoning powers. Feel motivated and energized, we can overcome almost anything. Feeling bored and restless, our minds shut off and we become increasingly passive.