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The bottom line of comedy is to be funny, and the bottom line of drama is to be truthful. You can be truthful and funny, but if you're not truthful in a drama than the audience leaves you.

"Eddie Izzard Talks TREASURE ISLAND, Possibility of a Sequel, and MUNSTERS Reboot MOCKINGBIRD LANE". Interview with Christina Radish, collider.com. May 1, 2012.
The bottom line of comedy is to be funny, and the bottom line of drama is to be truthful. You can be truthful and funny, but if you're not truthful in a drama than the audience leaves you.