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I actually tried to think of the story [Room] in gender-neutral terms at first and said to myself, "OK, would this work if it were a man?" Well no, you can't make a man pregnant, so it's got to be a woman.

"‘Room’ Author/Screenwriter Emma Donoghue on Her “Deeply Feminist” Film and Industry Sexism". Interview with Laura Berger, blogs.indiewire.com. October 16, 2015.
I actually tried to think of the story [Room] in gender-neutral terms at first and said to myself, OK, would this work if it were a man? Well no, you can't make a man pregnant, so it's got to be a woman.