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One must exploit the asynchronies that have befallen one, link them to a promising issue or domain, reframe frustrations as opportunities, and, above all, persevere.

Howard Gardner (1998). “Extraordinary Minds: Portraits Of 4 Exceptional Individuals And An Examination Of Our Own Extraordinariness”, p.135, Basic Books
One must exploit the asynchronies that have befallen one, link them to a promising issue or domain, reframe frustrations as opportunities, and, above all, persevere.