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The only thing that can effect a big change in personality is something that physically rewires the brain and/or alters the body's chemical milieu.

Neal Stephenson
Personality, Brain, Body
"Neal Stephenson Speaks about His Latest Epic: 'Seveneves'". Interview With Adrian Liang, www.amazonbookreview.com. May 21, 2015.
The only thing that can effect a big change in personality is something that physically rewires the brain and/or alters the body's chemical milieu.