Drama is a complete meal, vitamins, proteins, carbohydrates. It's a slow burn thing. It's got an arc. Comedy is more like coke.
If you get too well-known in comedy, I do believe it blocks people from taking you in drama.
The bottom line of comedy is to be funny, and the bottom line of drama is to be truthful. You can be truthful and funny, but if you're not truthful in a drama than the audience leaves you.